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Semaglutide activates these receptors, which may reduce neuroinflammation and stabilize neuronal firing patterns associated with migraine onset

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As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]